Title Inhibition of T cell activation through down-regulation of TCR-CD3 expression mediated by an anti-CD90 Ab
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چکیده
منابع مشابه
Inhibition of T cell activation through down-regulation of TCR-CD3 expression mediated by an anti-CD90 Ab.
We are trying to develop new Abs that can manipulate CD4 T cell responses and are usable as immunosuppressive agents. To this end, we performed functional screening, in which we examined the effect of an Ab on the proliferation of mouse CD4 T cells upon activation. The Ab, LP5, inhibited the activation of CD4 T cells stimulated with an anti-CD3 Ab or peptide antigen. The Ab alone had no stimula...
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